In the 19th century, New Yorkers flocked to collections of strange and grotesque oddities called "cabinets of curiosities." Now, in lower Manhattan, a modern apartment tower is slated to rise on the site of one of the old cabinets. Yet when the excavators break into a basement, they uncover a charnel pit of horror: the remains of thirty-six people murdered and gruesomely dismembered over 130 years ago by an unknown serial killer.

In the aftermath, FBI Special Agent Pendergast and museum archaeologist Nora Kelly embark on an investigation that unearths the faint whisper of a mysterious doctor who once roamed the city, carrying out medical experiments on living human beings. But just as Nora and Pendergast begin to unravel the clues to the century-old killings, a fresh spree of murder and surgical mutilation erupts around them. . . and New York City is awash in terror.